Hoodiadrene is a new, unique combination of ingredients that targets all aspects of weight loss. One powerful tablet is made up of the ingredients, Z-plex and Hoodia the promote the following
- Fat burning
- Appetite suppression
- Increase in energy and strength
- Elimination of dangerous side effects
- Use by both men and women
Boost your metabolism today with Hoodiadrene, an extra strength weight loss formula. Boasting a revolutionary blend of enriched thermogenic compounds that not only supports the body's metabolic rat, but increases your energy level to help promote weight loss and reduce boy fat.
The ingredient, Hoodia, used in Hoodiadrene was originally utilized by South African cultures as a natural appetite suppressant. Used for many centuries, South African bushmen often took Hoodia to stave off hunger while on extended hunting expeditions.
Hoodia, one of the exciting ingredients that is now used in Hoodiadrene, is a powerful supplement that will suppress your appetite like no other product you may have tried in the past. Hoodia takes aim at the root of the problem by simply eliminating your food cravings altogether. Although Hoodia has been used for centuries, it was rediscovered in a particular species of African cactus. The Hoodia extract has been the center of multiple clinical trials and has shown that it suppresses caloric intake in obese patients up to 40%-50%. Hoodia is one of Hoodiadrene's main active ingredients and it's potent extract is used in a 20:1 ratio making Hoodiadrene 20x more potent that the Hoodia plant itself. While most nutritional supplements have some amount of Hoodia in them, Hoodiarene has upwards of 400mg of pure Hoodia powder per serving.
The other active ingredient in Hoodiadrene is Z-plex, which contains Advantra Z, an extract of the Chinese herb, zhi-shi (immiture Bitter Orange, Citrus aurantium). The extract, zhi-shi, contains particular alkaloids that are connected to ephedrine alkaloids and have very similar effects on metabolism and the breaking down of body fat by increasing metabolic rate. The alkaloids present in Advantra Z include synephrine, hordenine, octopamine, lyramine and N-methylyramine.
The Details about Hoodiadrene
While foods and medicinal herbs have been continuously used for cooking and their health benefits, they have never before been utilized for their uses for weight loss, improved physical performance or fitness. That is partially due to the fact that the highest level of active ingredients are most often found in plants that are not typically eaten or plants still in an immature growth stage. To put it in perspective, you would need to drink 40 pints of orange juice or eat 80 oranges to even get close to the amount of Advantra Z that is obtained from one of two capsules of Hoodiadrene.
The main adrenergic amines (alkaloids of the citrus extract, Advantra Z, are synephrine and N-methyltyramine, which become active after they are eaten. Synephrine is used for medicinal purposes in Europe, but has been replaced by ephedrine and other like sources in most areas in North America. In clinical tests, citrus alkaloids have show properties similar to ephedrine (Goodmore and Gilman, 1941), by the activation of B-receptors (Munson, 1995). More recently studies on octopamine and synephrine have shown they are effective in stimulating lipolysis which drives fat burning in which synephrine showed to be the more effective ingredient. These studies also showed that the alkaloid mix in Advantra Z may work BETTER by affecting B-receptors in general.
This theory that Advantra Z may be superior in fat loss does not reap the side effects that other weight loss ingredients have in the past however. Initial studies in a multitude of volunteers both lean and obese have shown that they had excellent thermogenic responses, which failing to indicated any increase in heart rate, blood pressure or central nervous system stimulation. One clinical study that was reported by Colker et al. (1999) ran their study with a total absence of side effects.
Through studies, Citrus alkaloids appear to be as thermogenic as ephedrine alkaloids. They have proven they are clearly gentler than ephedrine and they do not cause the side effects commonly associated with ephedrine including nervousness, agitation, heart palpitations and increases in blood pressure. Citrus alkaloids are though to be more accepted by the body because they do not pass readily into the brain, but attack fat cells specifically.
The actions of Advantra Z can best be characterized as a mild, indirect acting sympathicomimetic agent, which commonly causes an elicit release of noradrenaline from presynaptic sites. This is responsible for activating both a and b-receptors. When studying Advantra Z alkaloids, however, there is certain evidence that shows domaine is also realease from the presynaptic sites (Hedrei & Gougeon, 1997). It appears that dopamine is present, but is only a precursor for noradrenaline. As far as noradrenaline is concerned, the perceived effects multiple organs and tissues depend on the relative proportions of both the a and b-receptors which commonly mediate different responses. Classic pharmacology teaches us that a receptor activation results when a smooth muscle (excluding the intestinal muscles) contracts, while b-receptors activate causing relaxation of smooth muscle and stimulation of the mycardium, or muscle around the heart. This is complicated by the fact that both a and b-receptors can be subdivided into further types with different distribution and sensitivities. This may be even further complicated by the possibility that a sensitivity to dopamine may not parallel those for noradrenaline.
At a cellular level, activation of B-receptors results in a stimulation of adenylate cyclase. This leads to an increase in intracellular level of cyclic adenosine monophosphate (cAMP) that in turn results in a number of observed reactions.
The subdivision of b-receptors is possible and they can be broken down into b1, b2 and b3 varieties. The b3 receptors is the receptor that is believed to be responsible for the lipolytic and thermogenic effects of adrenergic agents, while the other 2 subdivisions of the b-receptor are solely responsible for cardiac effects. Blood pressure is affected in part due to the a-receptors being activated.
The central nervous system is affected when adrenergic agents appear to be dependent on the activiation of the a and b-receptors, minus the b3 receptor. Response from multiple receptors at one time is important in explaining the synergistic effects on adrenegic agents when chemicals such as caffeine are introduced into the mix.
The overall response to agents such as the adrenegic agents is ruled by the amount of distribution of each type of receptor. For example, when b-receptors are activated, it causes a vasodilation of vessels in the certain areas of the body, mainly the heart and skeletal muscle, which simultaneously a-receptors that are activated result in vasoconstriction in other vascular areas. This is categorized as the "fight or flight" response, which together with other metabolic stressors and receptor activation can result in the optimal state of physical exertion.
The metabolic results of adrenoceptor activation also includes effects on lipolysis and thermogenesis. Especially with lipolysis, activation of certain a-receptors does not allow the process, which b3-receptors stimulates it. The overall response of the adipose tissue thus depends on the b3-receptors working with the a-receptors in somewhat relative harmony. The diminished of thermogenic response associated with an increased amount of a-receptors, may explain why some studies of thermogenic responses to adrenegic activation identify two populations: responders and second-hand responders.
Though the actions of adrengergic agents is a widely accepted explanation, the original clinical observations with the Advantra Z alkaloids did not reveal and affects on the heart nor the central nervous system which typically showed during tests of ephedrine alkaloids from Ephedra sinica. Those same trials however on Advantra Z showed a substantial effect on weight loss and fat loss (Colker et al., 1999).
The lack of effect of the nervous system can be explained due to the the relatively low lipophilicity of the Citrus alkaloids, which immensely slow down the blood-brain barrier. The absence of cardiovascular activity implies that Advantra Z alkaloids have little to no effect on any of the a and b-receptors except for the b3-receptor which it stimulates.
Part of the explanation for it only affecting the b3-receptor would be Advantra Z alkalods appear to release chemicals such as dopamine and noradrenaline from the presynaptic sites. While re-uptake of noradrenaline is common satisfactory, the dopamine released would remain in the synaptic gap for longer, in turn prolonging the activation of b3-receptors.
Recent studies have shown that both octopamine and synephrine have the ability to provoke b3-receptors as well, specifically in mammals (Carpene et al. 1999; Fontana et al., 2000). Previously it had been demonstrated that octopmaine had a significant lipolytic effect, but that synephrine was up to 3x more potent also indicating Advantra Z targets the stimulation of b3-receptors as well.
While there is some evidence from receptor studies that shows Advantra Z alkaloids show specificity for b3-receptors, the experimental evidence from studies in humans suggests strongly that this is one of the main mechanisms of action responsible:
In volunteers, no evidence of heart effects after single or repeated doses, but an increased metabolic rate.
In obese volunteers, significant increases in weight loss, particularly a loss in fat, but still no evidence of side effects or changes in cardiovascular parameters.
These observations indicate the relative absence of effects when dealing with b1 and b2-receptors, but a high effect on b3-receptors. It has not yet been determined whether this is due to peripheral dopamine effects or is a consequence of disassociation of the alkaloids actions or a result of both processes.
Metabolic rate is the key. As it increases, weight loss is improved greatly.
While actions of adrenergic agents demonstrate good thermogenesis without any side effects, they are ideal for regulating and controlling weight problems. They can also be helpful in aiding physical performance (Yang and McElligott, 1989). The action hoped to achieve is increased energy, increase capability of physical exertion and an increase muscle mass, particularly when paired with diet and training. By increasing the the rate at which fat is released from the body, it will simultaneously increase metabolic rate (thermogenesis) while increase the rate at which fat is removed.
In addition, since there is an increased amount of fatty acids for oxidation, the body has access to greater amounts of energy. The body also lets go of protein that may otherwise be used for energy. Taking an extra amount of protein in and utilizing an exercise program, may result in an increased muscle mass.