Spectral.DNC-N is the first treatment to employ Nanoxidil 5%, a powerful new alternative, with high efficacy, low molecular weight, and no side effects. The breakthrough system:
Many users disappointed by minoxidil see more and better hair with this formula
Men and women disappointed with mass-market minoxidil products often enjoy higher performance from Spectral.DNC-N because it contains more powerful compounds and fewer reported side effects. The rich formula is indicated for thinning that is clearly visible and not confined to the vertex (crown) of the scalp.
Unlike common minoxidil lotions and foams, Spectral.DNC-N delivers a broad range of ingredients that perform through complementary pathways. They work at the hairline as well as at the vertex, and they work for women as well as for men.
The formula offers:
Nanoxidil, a powerful compound more effective than commercial-grade minoxidil, Procyanidin B-2 for the hairline, retinol for absorption, adenosine for cell repair, and Aminexil® to fight perifollicular fibrosis, Copper peptides to counter inflammation and herbal extracts to improve overall condition, A Nanosome-encapsulation system to transport compounds deeper into the skin for longer performance and better efficacy, and Natural texture and comfortable feel.
Sustained application of Spectral.DNC-N means effective hair restoration similar to that of strong pharmaceuticals, but more naturally, without the side effects associated with drugs.
So both women and men can keep more of their hair longer and stronger.
First Nanoxidil-based topical solution reveals optimal hair at every stage of life
Spectral.DNC-N can maintain delicate follicles in their healthiest possible state to produce optimal hair at every stage of life because it is the first treatment to employ Nanoxidil 5%, a complex new compound developed as an alternative to minoxidil.
Nanoxidil is combined with Aminexil®, adenosine, procyanidin B-2, citrulline, copper peptides, T-flavanone, and additional hair-support agents. The formula performs well for many patients who may not have responded to minoxidil or may not have tolerated its side effects.
A product of cutting-edge research, the formula incorporates ingredients proven most effective via clinical trials, including data collected from human volunteers. Materials that did not show efficacy in studies, especially double-blind placebo-controlled trials, were rejected.
Within the complex biology of the scalp, Spectral.DNC-N establishes the highest possible efficacy from a topical application, combining beneficial molecules in a way that potentiates desirable properties and mitigates undesirable effects.
A more global approach to treatment, the product is intended both for the vertex (crown) of the scalp and for the frontal hairline.
Follicles cycle through three phases: anagen (growth), catagen (regression), and telogen (resting). In successive cycles, a follicle replaces its hair strand with another that may be either the same size or finer (balding) or thicker (treated). Some newly discovered compounds stimulate follicles to produce longer, darker hairs.
Anagen phase may last two to five years for long scalp hairs, or just a few weeks for short body hairs. Rates of growth are similar. In androgenetic alopecia (male pattern baldness), hormones induce follicles to miniaturize and produce vellus (light) hairs.
Despite decades of intense research and interest, our understanding of follicle function remains rudimentary.
DS Laboratories research
The oldest known ingredient for hair growth, minoxidil, works only on part of the scalp and only for a subset of users. The chemical sometimes causes side effects, commonly itching, burning of eyes, and irritation at the application site. Less common side effects can include allergic reaction, chest pain, dizziness, and rapid heartbeat. Alcohol used in common minoxidil products can dry the scalp, with its own adverse effects.
A leader in the biotechnology of hair, DS Laboratories has researched in molecular detail the etiology of hair thinning and shedding. While developing newer, more advanced alternatives to minoxidil, special attention has been focused on compounds that affect four factors of the hair-growth cycle: epithelial cells, the peripheral nervous system, the immune system, and the vascular system.
Equal attention is paid to absorption characteristics, as some compounds have beneficial effects at certain locations, such as the dermal papilla in the base of the follicles, but no effects at other locations, like the surface of the scalp.
To optimize delivery, this formula employs microspheres called Nanosomes, which encapsulate active molecules in solution. Nanosomes enhance the action of each ingredient, resulting in improved efficacy.
Another important aspect of DS Laboratories’ research is ensuring that the efficacy of a formula does not diminish over time, as commonly happens with topical therapies.
All combined, these high-performance technologies mean that Spectral.DNC-N can be your most powerful weapon in the fight against thinning or shedding hair, working faster and more effectively than common hair-growth brands, with better tolerability and no known side effects.
So users maintain thick, healthy-looking hair, appearing younger longer to pursue their optimal lives.
Many powerful compounds combine in this breakthrough hair support system
The compounds used in Spectral.DNC-N, detailed below, have shown in various studies to open ion channels within cells, suppress dihydrotestosterone (DHT), prevent perifollicular fibrosis, provide antioxidant effects, prolong the anagen phase of hair follicles, increase expression of vascular endothelial growth factor, suppress protein-kinase-C (PKC) isozymes, and block chronic inflammation.
These compounds may also exert beneficial effects on other processes that are not yet fully understood. The use of Nanosomes helps to enhance significantly the deposition of these substances into the skin and to prolong their actions.
Nanoxidil for the vertex of the scalp
When applied topically, the compound is believed to stimulate hair follicles on the vertex of the scalp, although the compound is relatively new, and the exact mechanism of action is not yet fully understood.
Ways in which Nanoxidil may work include: 1) the stimulation of follicular cells into the proliferative period of the hair cycle (anagen phase), 2) the stimulation of resting follicles (telogen phase) into anagen phase, and 3) the inhibition of androgen metabolism and its capacity to affect hair follicles.
Developed by DS Laboratories, the proprietary Nanoxidil compound was recently assigned a standardized name in accordance with the International Nomenclature Committee.
Aminexil® to strengthen roots
The patented molecule Aminexil is one of the most widely studied and proven hair-growth agents because in clinical trials it is shown to protect roots, preserve hair, and strengthen fibers. The compound emerged from 10 years of proprietary research conducted in L’Oreal laboratories.
Hairs can fall out after roots become rigid and compress the blood vessels that nourish them. In androgenic alopecia, the problem starts at both the hairline and the vertex, then spreads. Hairs get progressively finer, each with a shorter life span, until they disappear altogether.
Innovative Aminexil (diaminopyrimidine oxide) prevents this premature aging, called rigidification of collagen. Once captured by the hairs’ roots, the Aminexil preserves the suppleness and elasticity of the tissues that surround them. This method of action helps to build new hair fibers thicker, denser, and stronger.
In one trial with 120 men, hair shedding began to slow after as little as three weeks. Hair also became softer to the touch. In a placebo-controlled trial with 130 men, an additional eight percent of hair was maintained in anagen-growth phase after six weeks of Aminexil use.
These clinical results indicate that Spectral.DNC-N, with Aminexil, has the ability to preserve the vital functioning of roots, so they can build more and stronger hair fibers.
Adenosine for energy transfer in follicles
The adenosine nucleoside plays an important role in hair growth because it works in biochemical processes like energy transfer (adenosine triphosphate, adenosine diphosphate) and signal transduction (cyclic adenosine monophosphate).
This potent anti-inflammatory is under much study for hair growth and wound healing. For androgenic alopecia, adenosine is believed to regulate the expression of fibroblast growth factor 7 and vascular endothelial growth factor in dermal papilla cells.
Investigators assessed 101 volunteers in a randomized double-blind trial, comparing an adenosine 0.75% topical lotion against one with niacinamide 0.1%. They applied the lotions twice daily for six months, then evaluated the ratio of vellus (light) hairs to terminal (thick) hairs. For increasing the ratio of terminal hairs, as well as for global improvement, adenosine proved superior to niacinamide, producing a higher ratio of terminal hairs and lower ratio of vellus hairs. Side effects were not found.
This emerging science means that adenosine in Spectral.DNC-N can stimulate hair without side effects to help users restore their normal lifestyles.
Polyphenol from Malus domestica extract
Spectral.DNC-N contains procyanidin B-2, a polyphenol derived naturally from Malus domestica, because current research associates the extract with measurable improvement of the hairline as well as the vertex of the scalp.
Epithelial cells of a hair follicle include an outer root sheath, inner root sheath, and bulb matrix. But dermal papilla cells, which nourish the growing root of the hair fiber, are mesenchymal cells, more like bone and connective tissue. Successful hair growth relies on smooth interaction between these two cell types.
Procyanidin B-2 promotes this healthy interaction to allow for anagen-phase hair growth. Such stimulation may be all that is required to overcome some cases of hair thinning.
One laboratory study compared hair regrowth after 19 days of treatment with procyanidin B-2, minoxidil, or a placebo. Hair on the backs of mice was shaved, and a topical solution was applied daily. The effectiveness of procyanidin B-2 and minoxidil were similar for inducing anagen-phase hair growth.
In a subsequent double-blind clinical trial with humans, researchers investigated the effects of a 1% procyanidin B-2 solution over four months. Nineteen Japanese men received the procyanidin; 10 received a placebo.
In the procyanidin group, 79 percent showed greater hair diameter, compared to 30 percent in the placebo group. The treated group also showed a higher ratio of hairs over 40 micrometers in diameter and a higher total number of hairs.
This promising research means that Spectral.DNC-N, which delivers procyanidin B-2 in high concentration, applies multiple methods of action to help restore the hairline as well as the vertex.
Citrulline to supplement amino-acid deficiency
Spectral.DNC-N is fortified with citrulline, a crystalline amino acid formed in the conversion of ornithine to arginine and found in the inner root sheath and medulla of hair follicles.
Citrullinemia, a disorder of amino-acid metabolism, is associated with skin and scalp changes like atrophy of the epidermis, thin and short collagen bundles, and dystrophic elastic fibers. With a diagnosis of reduced citrulline, researchers have noted changes such as brittle blond strands and the presence of transverse opaque bands.
Amino-acid analysis has shown that relaxers used to straighten African hair often damage the strands, leaving them shorter than expected. A decrease in citrulline was found in all relaxed hair studied. Relaxers have been associated with inflammation as well.
The citrulline formulated into Spectral.DNC-N helps to supplement any deficiency.
Copper-peptide technology to stimulate growth
In Spectral.DNC-N, amino acid groups known as copper peptides have two major properties: 1) as anti-inflammatory agents that limit oxidative damage after tissue injury and 2) as tissue remodeling agents that remove damaged protein and scar tissue and activate their replacement with normal tissue.
Copper peptides are applied to enhance wound healing, they can stimulate the production of collagen, and they may enhance the action of antioxidants. Studies have found that copper peptides improve hair transplant success, increase hair follicle size, stimulate hair growth, and reduce hair loss.
In one study, scientists at the University of San Francisco Wound Center who applied copper peptides to human patients found that severe wounds healed 30 percent faster and that follicular cells displayed significant stimulation.
One tripeptide complex grew new hair in the wound area. The discovery led them to apply the copper peptide complex on a female patient with 90 percent alopecia. After six months, she recovered almost all of her hair. Subsequent tests were conducted with chemotherapy and hair-transplant patients, with great success.
Stem cells to support follicle regeneration
Spectral.DNC-N outperforms mass-market treatments in part by incorporating plant-based stem cells.
In the scalp, epithelial stem cells differentiate into hair follicles, sebaceous glands, or epidermis. Each lineage maintains its own reservoir of stem cells for the renewal of tissues. In response to disease or injury, the stem cells mobilize to repair tissues whose resident cells have been damaged or removed.
Normally, this robust regenerative capacity maintains hair growth throughout our lifetimes. When follicles malfunction, however, an understanding of how stem cells repair wounds is important to an understanding of how they can help to regrow hair.
Morphology: At the site of each hair is a bulge of cells that divide less frequently than other epithelial cells. They are activated at the start of each growth cycle to generate a new follicle.
In one laboratory experiment, stem cells from a single bulge were removed from a hairy mouse and grafted onto a hairless mouse. They generated new follicles that cycled normally. In another study, when confronted with stem cells taken from the wing of a chick, epidermis from its leg actually produced feathers.
Human epidermal cells also show this remarkable plasticity — this feature of “stemness.” Researchers have identified approximately 150 genes expressed preferentially in bulge cells relative to basal cells.
The scalp and its appendages — hair follicles and sebaceous glands — provide protective barriers that keep microbes out and bodily fluids in. They resist wounds and environmental assaults through continuous self renewal.
Hair-growth cycle: Stem cells proliferate in the stratum basale (also called stratum germinativum), which is the basal layer of epidermal cells. They divide to replace the keratin-rich cells of the stratum corneum as those cells migrate toward the surface and slough away.
In the scalp, the primary epidermal appendages are called pilosebaceous units. They contain follicles to manufacture hair and sebaceous glands to lubricate surfaces. Morphogenesis begins with a downward incursion of the epidermis into the underlying dermis to form a placode (area of thickening), in a process dependant on cues from neighboring cells. Underlying dermal cells condense to form a papilla, which is the vascular process that will nourish the root.
The follicle becomes encapsulated in a rich matrix of cells. Then a bulb of stem cells, located midway down the follicular process, proliferates to form an inner root sheath, which will act as a channel to guide the growing hair shaft.
A period of hair growth, called anagen phase, normally lasts a few years. The next phase, called catagen, lasts a few weeks and involves the apoptosis and disappearance of the lower two thirds of the follicle. The dermal papilla migrates up toward the bulge, and the remains of the follicle enter a resting phase, called telogen.
Except when affected by androgenic alopecia (male pattern baldness) or some disease, a single follicle cycles many times throughout a person’s life. The cyclic nature of degeneration and regeneration has led to the discovery that stem cells are concentrated in the bulge. Even without alopecia, anagen phase shortens, and telogen phase lengthens in aging scalps.
Stem cells in Spectral.DNC-N: Our new understanding of stem cells means exciting developments in biotechnical formulas for hair. We know that embryonic stem cells can develop into any tissue, that normal skin has reserves of such cells to regenerate itself after wounding, and that stem cells from one animal can develop into hair follicles in another animal.
New applications for stem cells would be to treat hair follicle disorders. Cultured basal epidermal keratinocytes already treat burn patients. However, human stem cells are difficult to access, and their use is fraught with ethical dilemmas.
Spectral.DNC-N overcomes these hurdles by employing plant-based stem cells, which exhibit many of the same properties and much of the same plasticity as human cells. An evolutionary botanical agent derived from plant stem cells now shows evidence of protecting and stimulating human epidermal stem cells and preventing many of the signs of scalp aging.
Current experimentation demonstrates in vitro that active phyto-compounds can stimulate the growth of human mesenchymal stem cells and help to protect them from attack by ultraviolet radiation.
In experiments conducted on hair follicles, plant-based stem-cell extracts have rejuvenated follicular cells and delayed their senescence.
Spectral.DNC-N offers unprecedented new potential to prolong the health of the human scalp and the productivity of its hair follicles, delaying scalp issues.
Apply six pumps twice per day directly in the area of hair thinning. Rub the liquid evenly over the entire area and wash hands with soap and water immediately after use. Do not rinse. Spectral.DNC-N should be applied whether hair has been washed or not.
Spectral.DNC-N must be used as directed without interruption. A sudden interruption or pause for a few days can cause extensive shedding and loss of progress.
DS Laboratories recommends that users make Spectral.DNC-N a regular part of their daily hair-care routine and that careful plans be made to ensure an adequate supply when planning to travel.
Contraindications for use
This formula is contraindicated in individuals with a history of sensitivity reactions to any of its components. It should be discontinued if hypersensitivity to any of its ingredients is noted.
Do not exceed the directed dosage because results would not be better or more rapid, but chances of side effects would be increased.
Spectral.DNC-N is for topical use only. If irritation develops, discontinue and consult your doctor. For adult use only, this product should not be used by pregnant women. Keep out of reach of children.
This product contains Nanosomes that increase absorption. Their use may cause enhanced absorption of other components as well, and this action may increase the chance of side effects from the other products. Exercise caution if combining.